Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS.

ABSTRACT:

Background

Decreased but measurable serum IgA levels (≤70 mg/dL) have been associated with risk for infections in some populations, but are unstudied in COPD. This study tested the hypothesis that subnormal serum IgA levels would be associated with exacerbation risk in COPD.

Methods

Data were analyzed from 1,049 COPD participants from the observational cohort study SPIROMICS (535 (51%) women; mean age 66.1 (SD 7.8), 338 (32%) current smokers) who had baseline serum IgA measured using the Myriad RBM biomarker discovery platform. Exacerbation data was collected prospectively (mean 944.3 (SD 281.3) days), and adjusted linear, logistic and zero-inflated negative binomial regressions were performed.

Results

Mean IgA was 269.1 mg/dL (SD 150.9). One individual had deficient

SUBMITTER: Putcha N 

PROVIDER: S-EPMC5896903 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature