Serum microRNA profiles in athyroid patients on and off levothyroxine therapy.

ABSTRACT:

Background

Levothyroxine replacement treatment in hypothyroidism is unable to restore physiological thyroxine and triiodothyronine concentrations in serum and tissues completely. Normal serum thyroid stimulating hormone (TSH) concentrations reflect only pituitary euthyroidism and, therefore, novel biomarkers representing tissue-specific thyroid state are needed. MicroRNAs (miRNAs), small non-coding regulatory RNAs, exhibit tissue-specific expression patterns and can be detectable in serum. Previous studies have demonstrated differential expression of (precursors of) miRNAs in tissues under the influence of thyroid hormone.

Objective

To study if serum miRNA profiles are changed in different thyroid states.

Design and methods

We studied 13 athyroid patients (6 males) du

SUBMITTER: Massolt ET 

PROVIDER: S-EPMC5896904 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature