Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast.

ABSTRACT: Metabolic dysregulation leading to sugar-phosphate accumulation is toxic in organisms ranging from bacteria to humans. By comparing two models of sugar-phosphate toxicity in Saccharomyces cerevisiae, we demonstrate that toxicity occurs, at least in part, through multiple, isomer-specific mechanisms, rather than a single general mechanism.

SUBMITTER: Gibney PA 

PROVIDER: S-EPMC5896929 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature