A Bayesian approach to modelling the impact of hydrodynamic shear stress on biofilm deformation.

ABSTRACT: We investigate the feasibility of using a surrogate-based method to emulate the deformation and detachment behaviour of a biofilm in response to hydrodynamic shear stress. The influence of shear force, growth rate and viscoelastic parameters on the patterns of growth, structure and resulting shape of microbial biofilms was examined. We develop a statistical modelling approach to this problem, using combination of Bayesian Poisson regression and dynamic linear models for the emulation. We observe that the hydrodynamic shear force affects biofilm deformation in line with some literature. Sensitivity results also showed that the expected number of shear events, shear flow, yield coefficient for heterotrophic bacteria and extracellular polymeric substance (EPS) stiffness per unit EPS mass are

SUBMITTER: Oyebamiji OK 

PROVIDER: S-EPMC5896950 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature