Critical assessment of methods of protein structure prediction (CASP)-Round XII.

ABSTRACT: This article reports the outcome of the 12th round of Critical Assessment of Structure Prediction (CASP12), held in 2016. CASP is a community experiment to determine the state of the art in modeling protein structure from amino acid sequence. Participants are provided sequence information and in turn provide protein structure models and related information. Analysis of the submitted structures by independent assessors provides a comprehensive picture of the capabilities of current methods, and allows progress to be identified. This was again an exciting round of CASP, with significant advances in 4 areas: (i) The use of new methods for predicting three-dimensional contacts led to a two-fold improvement in contact accuracy. (ii) As a consequence, model accuracy for proteins where no templat

SUBMITTER: Moult J 

PROVIDER: S-EPMC5897042 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature