Ontology highlight
ABSTRACT:
SUBMITTER: Tharp KM
PROVIDER: S-EPMC5897043 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Cell metabolism 20180301 3
The activation of brown/beige adipose tissue (BAT) metabolism and the induction of uncoupling protein 1 (UCP1) expression are essential for BAT-based strategies to improve metabolic homeostasis. Here, we demonstrate that BAT utilizes actomyosin machinery to generate tensional responses following adrenergic stimulation, similar to muscle tissues. The activation of actomyosin mechanics is critical for the acute induction of oxidative metabolism and uncoupled respiration in UCP1<sup>+</sup> adipocy ...[more]