Accurately Predicting Disordered Regions of Proteins Using Rosetta ResidueDisorder Application.

ABSTRACT: Although many proteins necessitate well-folded structures to properly instigate their biological functions, a large fraction of functioning proteins contain regions-known as intrinsically disordered protein regions-where stable structures are not likely to form. Notable functional roles of intrinsically disordered proteins are in transcriptional regulation, translation, and cellular signal transduction. Moreover, intrinsically disordered protein regions are highly abundant in many proteins associated with various human diseases, therefore these segments have become attractive drug targets for potential therapeutics. Over the past decades, numerous computational methods have been developed to accurately predict disordered regions of proteins. Here we introduce a user-friendly and reliable a

SUBMITTER: Kim SS 

PROVIDER: S-EPMC5897131 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature