Underregistration and Underreporting of Stem Cell Clinical Trials in Neurological Disorders.

ABSTRACT: BACKGROUND AND PURPOSE:Research on stem cells (SC) is growing rapidly in neurology, but clinical applications of SC for neurological disorders remain to be proven effective and safe. Human clinical trials need to be registered in registries in order to reduce publication bias and selective reporting. METHODS:We searched three databases-clinicaltrials.gov, the Clinical Research Information System (CRIS), and PubMed-for neurologically relevant SC-based human trials and articles in Korea. The registration of trials, posting and publication of results, and registration of published SC articles were examined. RESULTS:There were 17 completed trials registered at clinicaltrials.gov and the CRIS website, with results articles having been published for 5 of them. Our study found 16 publications, of

SUBMITTER: Lee TE 

PROVIDER: S-EPMC5897206 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature