Structural biology of GABA_B receptor.

ABSTRACT: Metabotropic GABA_B receptor is a G protein-coupled receptor (GPCR) that mediates slow and prolonged inhibitory neurotransmission in the brain. It functions as a constitutive heterodimer composed of the GABA_B1 and GABA_B2 subunits. Each subunit contains three domains; the extracellular Venus flytrap module, seven-helix transmembrane region and cytoplasmic tail. In recent years, the three-dimensional structures of GABA_B receptor extracellular and intracellular domains have been elucidated. These structures reveal the molecular basis of ligand recognition, receptor heterodimerization and receptor activation. Here we provide a brief review of the GABA_B receptor structures, with an emphasis on describing the different ligand-bound states of

SUBMITTER: Frangaj A 

PROVIDER: S-EPMC5897222 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature