Ontology highlight
ABSTRACT:
SUBMITTER: Chang HH
PROVIDER: S-EPMC5897574 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Scientific reports 20180412 1
Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus making PDAC amenable to preventive strategies. We aimed to characterize the chemo-preventive effects of metformin, a widely used anti-diabetic drug, on PDAC development using the Kras<sup>G12D</sup> mouse model subjected to a diet high in fats and calories (HFCD). LSL-Kras<sup>G12D/+</sup>;p48-Cre (KC) mice were given control diet (CD), HFCD, ...[more]