Identification of early indicators of altered metabolism in normal development using a rodent model system.

ABSTRACT: Although the existence of a close relationship between the early maternal developmental environment, fetal size at birth and the risk of developing disease in adulthood has been suggested, most studies, however, employed experimentally induced intrauterine growth restriction as a model to link this with later adult disease. Because embryonic size variation also occurs under normal growth and differentiation, elucidating the molecular mechanisms underlying these changes and their relevance to later adult disease risk becomes important. The birth weight of rat pups vary according to the uterine horn positions. Using birth weight as a marker, we compared two groups of rat pups - lower birth weight (LBW, 5th to 25th percentile) and average birth weight (ABW, 50th to 75th percentile) - using mo

SUBMITTER: Prabakaran AD 

PROVIDER: S-EPMC5897726 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature