Gene Unprediction with Spurio: A tool to identify spurious protein sequences.

ABSTRACT: We now have access to the sequences of tens of millions of proteins. These protein sequences are essential for modern molecular biology and computational biology. The vast majority of protein sequences are derived from gene prediction tools and have no experimental supporting evidence for their translation.  Despite the increasing accuracy of gene prediction tools there likely exists a large number of spurious protein predictions in the sequence databases.  We have developed the Spurio tool to help identify spurious protein predictions in prokaryotes.  Spurio searches the query protein sequence against a prokaryotic nucleotide database using tblastn and identifies homologous sequences. The tblastn matches are used to score the query sequence's likelihood of being a spurious protein predict

SUBMITTER: Hops W 

PROVIDER: S-EPMC5897793 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature