Enhanced stability of a chimeric hepatitis B core antigen virus-like-particle (HBcAg-VLP) by a C-terminal linker-hexahistidine-peptide.

ABSTRACT:

Background

Virus-like-particles (VLPs) are attractive nanoparticulate scaffolds for broad applications in material/biological sciences and medicine. Prior their functionalization, specific adaptations have to be carried out. These adjustments frequently lead to disordered particles, but the particle integrity is an essential factor for the VLP suitability. Therefore, major requirements for particle stabilization exist. The objective of this study was to evaluate novel stabilizing elements for functionalized chimeric hepatitis B virus core antigen virus-like particles (HBcAg-VLP), with beneficial characteristics for vaccine development, imaging or delivery.

Results

The effects of a carboxy-terminal polyhistidine-peptide and an intradimer disulfide-bridge on the stability of p

SUBMITTER: Schumacher J 

PROVIDER: S-EPMC5897928 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature