Evolution of computational models in BioModels Database and the Physiome Model Repository.

ABSTRACT:

Background

A useful model is one that is being (re)used. The development of a successful model does not finish with its publication. During reuse, models are being modified, i.e. expanded, corrected, and refined. Even small changes in the encoding of a model can, however, significantly affect its interpretation. Our motivation for the present study is to identify changes in models and make them transparent and traceable.

Methods

We analysed 13734 models from BioModels Database and the Physiome Model Repository. For each model, we studied the frequencies and types of updates between its first and latest release. To demonstrate the impact of changes, we explored the history of a Repressilator model in BioModels Database.

Results

We observed continuous updates in the maj

SUBMITTER: Scharm M 

PROVIDER: S-EPMC5898004 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature