A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N=223,773).

ABSTRACT:

Background

Headache is the most common neurological symptom and a leading cause of years lived with disability. We sought to identify the genetic variants associated with a broadly-defined headache phenotype in 223,773 subjects from the UK Biobank cohort.

Methods

We defined headache based on a specific question answered by the UK Biobank participants. We performed a genome-wide association study of headache as a single entity, using 74,461 cases and 149,312 controls.

Results

We identified 3343 SNPs which reached the genome-wide significance level of P<5×10^-8. The SNPs were located in 28 loci, with the top SNP of rs11172113 in the LRP1 gene having a P value of 4.92×10^-47. Of the 28 loci, 14 have previously been associated with migraine. Among 14 n

SUBMITTER: Meng W 

PROVIDER: S-EPMC5898025 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature