Salivary Glycopatterns as Potential Biomarkers for Screening of Early-Stage Breast Cancer.

ABSTRACT:

Objective

We systematically investigated and assessed the alterations of salivary glycopatterns and possibility as biomarkers for diagnosis of early-stage breast cancer.

Design

Alterations of salivary glycopatterns were probed using lectin microarrays and blotting analysis from 337 patients with breast benign cyst or tumor (BB) or breast cancer (I/II stage) and 110 healthy humans. Their diagnostic models were constructed by a logistic stepwise regression in the retrospective cohort. Then, the performance of the diagnostic models were assessed by ROC analysis in the validation cohort. Finally, a double-blind cohort was tested to confirm the application potential of the diagnostic models.

Results

The diagnostic models were constructed based on 9 candidate lectins (e.g.,

SUBMITTER: Liu X 

PROVIDER: S-EPMC5898026 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature