Esophagus-duodenum Gastric Bypass Surgery Improves Glucose and Lipid Metabolism in Mice.

ABSTRACT:

Background

Despite of its significant therapeutic effects on obesity and metabolic diseases, Roux-en-Y gastric bypass (RYGB) has limited clinical application because of considerable impacts on the gastrointestinal structure and postoperative complications. This study aims to develop a simplified surgical approach with less damage and complication but efficient metabolic benefit.

Methods

The effects of Esophagus-Duodenum gastric bypass (EDGB) on body weight, food intake, glucose and lipid metabolism were compared to RYGB in mice.

Findings

EDGB is simple, has higher survival rate and less complication. Relative to RYGB, EDGB demonstrated modest body weight control, identical improvement of glucose and lipid metabolism in obese mice. Blood glucose increased significantly

SUBMITTER: He R 

PROVIDER: S-EPMC5898028 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature