Treatment options in idiopathic subglottic stenosis: protocol for a prospective international multicentre pragmatic trial.

ABSTRACT:

Introduction

Idiopathic subglottic stenosis (iSGS) is an unexplained progressive obstruction of the upper airway that occurs almost exclusively in adult, Caucasian women. The disease is characterised by mucosal inflammation and localised fibrosis resulting in life-threatening blockage of the upper airway. Because of high recurrence rates, patients with iSGS will frequently require multiple procedures following their initial diagnosis. Both the disease and its therapies profoundly affect patients' ability to breathe, communicate and swallow. A variety of treatments have been advanced to manage this condition. However, comparative data on effectiveness and side effects of the unique approaches have never been systematically evaluated. This study will create an international, multi-in

SUBMITTER: Gelbard A 

PROVIDER: S-EPMC5898326 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature