Association between human leucocyte antigen-DO polymorphisms and interferon/ribavirin treatment response in hepatitis C virus type 1 infection in Chinese population: a prospective study.

ABSTRACT:

Objective

The human leucocyte antigen-DO (HLA-DO) gene located in the HLA non-classical class-II region may play a role in treatment response to hepatitis C virus (HCV). This study was conducted to explore the role of single nucleotide polymorphisms (SNPs) in HLA-DO in responding to HCV therapy.

Setting

All patients were recruited between January 2011 and September 2016 from the Jurong People's Hospital, Jiangsu Province, China.

Participants

A total of 346 chronic hepatitis C (CHC) patients who finished the 48-week pegylated interferon-alpha and ribavirin (PEG IFN-α/RBV) treatment were enrolled in this study. All patients were former remunerated blood donors. The inclusion criteria for patients were as follows: (1) treatment-naive and treat

SUBMITTER: Yao Y 

PROVIDER: S-EPMC5898346 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature