Quantifying and visualizing site performance in clinical trials.

ABSTRACT:

Background

One of the keys to running a successful clinical trial is the selection of high quality clinical sites, i.e., sites that are able to enroll patients quickly, engage them on an ongoing basis to prevent drop-out, and execute the trial in strict accordance to the clinical protocol. Intuitively, the historical track record of a site is one of the strongest predictors of its future performance; however, issues such as data availability and wide differences in protocol complexity can complicate interpretation. Here, we demonstrate how operational data derived from central laboratory services can provide key insights into the performance of clinical sites and help guide operational planning and site selection for new clinical trials.

Methods

Our methodology uses the meta

SUBMITTER: Yang E 

PROVIDER: S-EPMC5898563 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature