Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice.

ABSTRACT: The liver and the mammary gland have complementary metabolic roles during lactation. Substrates synthesized by the liver are released into the circulation and are taken up by the mammary gland for milk production. The aryl hydrocarbon receptor (AHR) has been identified as a lactation regulator in mice, and its activation has been associated with myriad morphological, molecular, and functional defects such as stunted gland development, decreased milk production, and changes in gene expression. In this study, we identified adverse metabolic changes in the lactation network (mammary, liver, and serum) associated with AHR activation using ¹H nuclear magnetic resonance (NMR)-based metabolomics. Pregnant mice expressing Ahr ^d (low affinity) or Ahr ^b (high affinit

SUBMITTER: Belton KR 

PROVIDER: S-EPMC5898790 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature