<i>Pseudomonas aeruginosa</i> adaptation and diversification in the non-cystic fibrosis bronchiectasis lung.

ABSTRACT: To characterise Pseudomonas aeruginosa populations during chronic lung infections of non-cystic fibrosis bronchiectasis patients, we used whole-genome sequencing to 1) assess the diversity of P. aeruginosa and the prevalence of multilineage infections; 2) seek evidence for cross-infection or common source acquisition; and 3) characterise P. aeruginosa adaptations.189 isolates, obtained from the sputa of 91 patients attending 16 adult bronchiectasis centres in the UK, were whole-genome sequenced.Bronchiectasis isolates were representative of the wider P. aeruginosa population. Of 24 patients from whom multiple isolates were examined, there were seven examples of multilineage infections, probably arising from multiple infection events. The number of nucleotide var

SUBMITTER: Hilliam Y 

PROVIDER: S-EPMC5898933 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature