Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis.

ABSTRACT: New approaches to control the spread of tuberculosis (TB) are needed, including tools to predict development of active TB from latent TB infection (LTBI). Recent studies have described potential correlates of risk, in order to inform the development of prognostic tests for TB disease progression. These efforts have included unbiased approaches employing "omics" technologies, as well as more directed, hypothesis-driven approaches assessing a small set or even individual selected markers as candidate correlates of TB risk. Unbiased high-throughput screening of blood RNAseq profiles identified signatures of active TB risk in individuals with LTBI, ≥1 year before diagnosis. A recent infant vaccination study identified enhanced expression of T-cell activation markers as a correlate of risk prio

SUBMITTER: Petruccioli E 

PROVIDER: S-EPMC5898936 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature