Physical Activity and Bone Accretion: Isotemporal Modeling and Genetic Interactions.

ABSTRACT:

Purpose

This study aimed to determine if replacing time spent in high- and low-impact physical activity (PA) predicts changes in pediatric bone mineral density (BMD) and content (BMC).

Methods

We analyzed data from the longitudinal Bone Mineral Density in Childhood Study (N = 2337 with up to seven visits). The participants were age 5-19 yr at baseline, 51.2% were female, and 80.6% were nonblack. Spine, total hip, and femoral neck areal BMD and total body less head (TBLH) BMC Z-scores were calculated. Hours per day spent in high- and low-impact PA were self-reported. Standard covariate-adjusted (partition model) and time allocation-sensitive isotemporal substitution modeling frameworks were applied to linear mixed models. Statistical interactions with sex, self-reported ances

SUBMITTER: Mitchell JA 

PROVIDER: S-EPMC5899052 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature