Associations of maternal and cord blood adipokines with offspring adiposity in Project Viva: is there an interaction with child age?

ABSTRACT:

Objectives

Higher leptin and lower adiponectin correlate with adult and childhood adiposity, but it is unclear how exposure to these adipokines during gestation relates to offspring growth. We aimed to investigate the relationships of maternal and cord adipokines with offspring adiposity across childhood to early adolescence, as well as interactions with child age.

Methods

In mother-child pairs in the Project Viva cohort, we measured adipokines in mothers at second trimester (n=1106) and in cord blood at birth (n=657). We measured offspring adiposity indices at early childhood (mean 3.3±s.d. 0.3 years), mid-childhood (7.9±0.8 years) and early adolescence (13.2±0.9 years). We analyzed associations of maternal and cord adipokines with offspring longitudinal adiposity using a l

SUBMITTER: Li LJ 

PROVIDER: S-EPMC5899068 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature