Rat models of 17β-estradiol-induced mammary cancer reveal novel insights into breast cancer etiology and prevention.

ABSTRACT: Numerous laboratory and epidemiologic studies strongly implicate endogenous and exogenous estrogens in the etiology of breast cancer. Data summarized herein suggest that the ACI rat model of 17β-estradiol (E2)-induced mammary cancer is unique among rodent models in the extent to which it faithfully reflects the etiology and biology of luminal types of breast cancer, which together constitute ~70% of all breast cancers. E2 drives cancer development in this model through mechanisms that are largely dependent upon estrogen receptors and require progesterone and its receptors. Moreover, mammary cancer development appears to be associated with generation of oxidative stress and can be modified by multiple dietary factors, several of which may attenuate the actions of reactive oxygen species. St

SUBMITTER: Shull JD 

PROVIDER: S-EPMC5899232 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature