Population-level distribution and putative immunogenicity of cancer neoepitopes.

ABSTRACT:

Background

Tumor neoantigens are drivers of cancer immunotherapy response; however, current prediction tools produce many candidates requiring further prioritization. Additional filtration criteria and population-level understanding may assist with prioritization. Herein, we show neoepitope immunogenicity is related to measures of peptide novelty and report population-level behavior of these and other metrics.

Methods

We propose four peptide novelty metrics to refine predicted neoantigenicity: tumor vs. paired normal peptide binding affinity difference, tumor vs. paired normal peptide sequence similarity, tumor vs. closest human peptide sequence similarity, and tumor vs. closest microbial peptide sequence similarity. We apply these metrics to neoepitopes predicted from somat

SUBMITTER: Wood MA 

PROVIDER: S-EPMC5899330 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature