Five-minute knee MRI for simultaneous morphometry and T₂ relaxometry of cartilage and meniscus and for semiquantitative radiological assessment using double-echo in steady-state at 3T.

ABSTRACT:

Background

Biomarkers for assessing osteoarthritis activity necessitate multiple MRI sequences with long acquisition times.

Purpose

To perform 5-minute simultaneous morphometry (thickness/volume measurements) and T₂ relaxometry of both cartilage and meniscus, and semiquantitative MRI Osteoarthritis Knee Scoring (MOAKS).

Study type

Prospective.

Subjects

Fifteen healthy volunteers for morphometry and T₂ measurements, and 15 patients (five each Kellgren-Lawrence grades 0/2/3) for MOAKS assessment.

Field strength/sequence

A 5-minute double-echo steady-state (DESS) sequence was evaluated for generating quantitative and semiquantitative osteoarthritis biomarkers at 3T.

Assessment

Flip angle simulations evaluated tissue signals and

SUBMITTER: Chaudhari AS 

PROVIDER: S-EPMC5899635 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature