Circulating biomarkers in extremely preterm infants associated with ultrasound indicators of brain damage.

ABSTRACT:

Aim

To assess to what extent the blood concentrations of proteins with neurotrophic and angiogenic properties measured during the first postnatal month convey information about the risk of sonographically-identified brain damage among very preterm newborns.

Methods

Study participants were 1219 children who had a cranial ultrasound scan during their stay in the intensive care nursery and blood specimens collected on 2 separate days at least a week apart during the first postnatal month. Concentrations of selected proteins in blood spots were measured with electrochemiluminescence or with a multiplex immunobead assay and the risks of cranial ultrasound images associated with top-quartile concentrations were assessed.

Results

High concentrations of multiple inflammation-

SUBMITTER: Leviton A 

PROVIDER: S-EPMC5899659 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature