Pulmonary ventilation imaging in asthma and cystic fibrosis using oxygen-enhanced 3D radial ultrashort echo time MRI.

ABSTRACT:

Background

A previous study demonstrated the feasibility of using 3D radial ultrashort echo time (UTE) oxygen-enhanced MRI (UTE OE-MRI) for functional imaging of healthy human lungs. The repeatability of quantitative measures from UTE OE-MRI needs to be established prior to its application in clinical research.

Purpose

To evaluate repeatability of obstructive patterns in asthma and cystic fibrosis (CF) with UTE OE-MRI with isotropic spatial resolution and full chest coverage.

Study type

Volunteer and patient repeatability.

Population

Eighteen human subjects (five asthma, six CF, and seven normal subjects).

Field strength/sequence

Respiratory-gated free-breathing 3D radial UTE (80 μs) sequence at 1.5T.

Assessment

Two 3D radial UTE volumes were acqu

SUBMITTER: Zha W 

PROVIDER: S-EPMC5899670 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature