Catheter-based endobronchial electroporation is feasible for the focal treatment of peribronchial tumors.

ABSTRACT:

Objective

To evaluate the feasibility of catheter-based endobronchial electroporation for the treatment of peribronchial tumors and assess the incidence of treatment-related adverse events.

Methods

Cytotoxicity of electroporation with or without cisplatin or gefitinib was assessed in vitro with lung cancer and normal cell lines. A novel catheter was designed for endobronchial electroporation, and computer simulations were used to predict in vivo treatment effects. Electroporation with the test catheter was performed (2000 V, 70 pulses) in the main bronchus of 8 pigs at 11 locations. Computed tomography imaging was performed before they were killed at 4 hours (6 animals) or 4 weeks (2 animals) posttreatment. Treated airway and surrounding parenchyma were compared with sham tr

SUBMITTER: Kodama H 

PROVIDER: S-EPMC5899684 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature