Hierarchical design of artificial proteins and complexes toward synthetic structural biology.

ABSTRACT: In multiscale structural biology, synthetic approaches are important to demonstrate biophysical principles and mechanisms underlying the structure, function, and action of bio-nanomachines. A central goal of "synthetic structural biology" is the design and construction of artificial proteins and protein complexes as desired. In this paper, I review recent remarkable progress of an array of approaches for hierarchical design of artificial proteins and complexes that signpost the path forward toward synthetic structural biology as an emerging interdisciplinary field. Topics covered include combinatorial and protein-engineering approaches for directed evolution of artificial binding proteins and membrane proteins, binary code strategy for structural and functional de novo proteins, protein na

SUBMITTER: Arai R 

PROVIDER: S-EPMC5899735 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature