Malignant Gliomas as Second Neoplasms in Pediatric Cancer Survivors: Neuropathological Study.

ABSTRACT: This study presents a unique series of malignant supratentorial gliomas in children previously cured from non-CNS primary cancer. On neuroimaging these tumors were not specific, so the patients were suspected of cerebral recurrence of their primary neoplasm: leukemia in four children and sarcoma in one child. Histologically, the group contained four glioblastomas and one anaplastic astrocytoma. Three patients underwent neurosurgical resection, while the other two underwent stereotactic diagnostic biopsy only. Despite combined oncological treatment, four children died during 20 months, and only one glioblastoma patient continued to live for another twelve years. Microscopically, the neoplasms consisted of small cells with some morphologic features of astrocytic lineage, having scanty or pro

SUBMITTER: Izycka-Swieszewska E 

PROVIDER: S-EPMC5899852 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature