Novel rodent model of breast cancer survival with persistent anxiety-like behavior and inflammation.

ABSTRACT: Breast cancer survivors are an expanding population that is troubled by lasting mental health problems, including depression and anxiety. These issues reduce quality-of-life throughout survivorhood. Research indicates that tumor biology, cancer treatments, and stress contribute to these mood disturbances. Although the mechanisms underlying these various causes remain under investigation, neuroinflammation is a leading hypothesis. To date, rodent models of recurrence-free tumor survival for understanding mechanisms by which these behavioral issues persist after cancer are lacking. Here, we test the extent to which potential behavioral symptoms persist after mammary tumor removal in mice (i.e., establishment of a cancer survivor model), while also empirically testing the causal role of tumor

SUBMITTER: Pyter LM 

PROVIDER: S-EPMC5899888 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature