High thickness histological sections as alternative to study the three-dimensional microscopic human sub-cortical neuroanatomy.

ABSTRACT: Stereotaxy is based on the precise image-guided spatial localization of targets within the human brain. Even with the recent advances in MRI technology, histological examination renders different (and complementary) information of the nervous tissue. Although several maps have been selected as a basis for correlating imaging results with the anatomical locations of sub-cortical structures, technical limitations interfere in a point-to-point correlation between imaging and anatomy due to the lack of precise correction for post-mortem tissue deformations caused by tissue fixation and processing. We present an alternative method to parcellate human brain cytoarchitectural regions, minimizing deformations caused by post-mortem and tissue-processing artifacts and enhancing segmentation by means

SUBMITTER: Alho EJL 

PROVIDER: S-EPMC5899898 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature