Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease.

ABSTRACT:

Objective

To identify rare causal variants underlying known loci that segregate with late-onset Alzheimer's disease (LOAD) in multiplex families.

Methods

We analyzed whole genome sequences (WGS) from 351 members of 67 Caribbean Hispanic (CH) families from Dominican Republic and New York multiply affected by LOAD. Members of 67 CH and additional 47 Caucasian families underwent WGS as a part of the Alzheimer's Disease Sequencing Project (ADSP). All members of 67 CH families, an additional 48 CH families and an independent CH case-control cohort were subsequently genotyped for validation. Patients met criteria for LOAD, and controls were determined to be dementia free. We investigated rare variants segregating within families and gene-based associations with disease within LOAD

SUBMITTER: Vardarajan BN 

PROVIDER: S-EPMC5899906 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature