Persistent organic pollutants and risk of type 2 diabetes: A prospective investigation among middle-aged women in Nurses' Health Study II.

ABSTRACT:

Background

Exposure to persistent organic pollutants (POPs) may predispose to the development of type 2 diabetes (T2D), but prospective human evidence is scarce.

Objectives

We investigated the association between plasma-POP concentrations in the late 1990s and incident T2D over 11 years of follow-up in the Nurses' Health Study II.

Discussion

Three organochlorine pesticides and 20 polychlorinated biphenyls (PCBs) were measured in banked plasma from 793 case-control pairs of T2D. In a multiviarate-adjusted model, T2D ORs (95%CIs) comparing extreme POP tertiles (high vs. low) were 1.67 (1.24, 2.23; P_trend < 0.001) for hexachlorobenzene (HCB), 3.62 (2.57, 5.11; P_trend < 0.001) for β-hexachlorocyclohexane (β-HCH), 1.55 (1.13, 2.13; P_trend =

SUBMITTER: Zong G 

PROVIDER: S-EPMC5899920 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature