Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer Immunotherapies.

ABSTRACT: The innate immune system provides the first line of defense against pathogen infection though also influences pathways involved in cancer immunosurveillance. The innate immune system relies on a limited set of germ line-encoded sensors termed pattern recognition receptors (PRRs), signaling proteins and immune response factors. Cytosolic receptors mediate recognition of danger damage-associated molecular patterns (DAMPs) signals. Once activated, these sensors trigger multiple signaling cascades, converging on the production of type I interferons and proinflammatory cytokines. Recent studies revealed that PRRs respond to nucleic acids (NA) released by dying, damaged, cancer cells, as danger DAMPs signals, and presence of signaling proteins across cancer types suggests that these signaling me

SUBMITTER: Iurescia S 

PROVIDER: S-EPMC5900005 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature