Inhibitory Neural Regulation of the Ca ²⁺ Transients in Intramuscular Interstitial Cells of Cajal in the Small Intestine.

ABSTRACT: Gastrointestinal motility is coordinated by enteric neurons. Both inhibitory and excitatory motor neurons innervate the syncytium consisting of smooth muscle cells (SMCs) interstitial cells of Cajal (ICC) and PDGFRα⁺ cells (SIP syncytium). Confocal imaging of mouse small intestines from animals expressing GCaMP3 in ICC were used to investigate inhibitory neural regulation of ICC in the deep muscular plexus (ICC-DMP). We hypothesized that Ca²⁺ signaling in ICC-DMP can be modulated by inhibitory enteric neural input. ICC-DMP lie in close proximity to the varicosities of motor neurons and generate ongoing Ca²⁺ transients that underlie activation of Ca²⁺-dependent Cl^- channels and regulate the excitability of SMCs in the SIP syncytium. Ele

SUBMITTER: Baker SA 

PROVIDER: S-EPMC5900014 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature