MiR-466a Targeting of TGF-β2 Contributes to FoxP3⁺ Regulatory T Cell Differentiation in a Murine Model of Allogeneic Transplantation.

ABSTRACT: The promise of inducing immunological tolerance through regulatory T cell (Treg) control of effector T cell function is crucial for developing future therapeutic strategies to treat allograft rejection as well as inflammatory autoimmune diseases. In the current study, we used murine allograft rejection as a model to identify microRNA (miRNA) regulation of Treg differentiation from naïve CD4 cells. We performed miRNA expression array in CD4⁺ T cells in the draining lymph node (dLN) of mice which received syngeneic or allogeneic grafts to determine the molecular mechanisms that hinder the expansion of Tregs. We identified an increase in miRNA cluster 297-669 (C2MC) after allogeneic transplantation, in CD4⁺ T cells, such that 10 of the 27 upregulated miRNAs were all from

SUBMITTER: Becker W 

PROVIDER: S-EPMC5900016 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature