Modeling the Electrophysiological Properties of the Infarct Border Zone.

ABSTRACT: Ventricular arrhythmias (VA) in patients with myocardial infarction (MI) are thought to be associated with structural and electrophysiological remodeling within the infarct border zone (BZ). Personalized computational models have been used to investigate the potential role of the infarct BZ in arrhythmogenesis, which still remains incompletely understood. Most recent models have relied on experimental data to assign BZ properties. However, experimental measurements vary significantly resulting in different computational representations of this region. Here, we review experimental data available in the literature to determine the most prominent properties of the infarct BZ. Computational models are then used to investigate the effect of different representations of the BZ on activation and

SUBMITTER: Mendonca Costa C 

PROVIDER: S-EPMC5900020 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature