EGFR amplification induces sensitivity to antiEGFR therapy in pancreatic acinar cell carcinoma.

ABSTRACT: Pancreatic acinar cell carcinoma (PACC) is a rare cancer. When the tumor is metastatic, few therapeutic options are available. Precision medicine using next-generation sequencing is defined by the administration of drugs based on the tumor genetic mutations. The usage of precision medicine for finding new therapeutic options for rare cancers is an emerging field. We have reported here the case of a patient bearing a multitreated metastatic PACC. This patient underwent somatic and constitutional exome analyses. The analyses revealed in the liver metastasis an amplification of the EGFR gene. Accordingly, the patient was treated with off-label usage of panitumumab. We observed rapid response with necrosis of the liver metastasis, while no efficacy was observed in the primary tumor. An exome a

SUBMITTER: Richard C 

PROVIDER: S-EPMC5900454 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature