Urinary Excretion of Niacin Metabolites in Humans After Coffee Consumption.

ABSTRACT:

Scope

Coffee is a major natural source of niacin in the human diet, as it is formed during coffee roasting from the alkaloid trigonelline. The intention of our study was to monitor the urinary excretion of niacin metabolites after coffee consumption under controlled diet.

Methods and results

We performed a 4-day human intervention study on the excretion of major niacin metabolites in the urine of volunteers after ingestion of 500 mL regular coffee containing 34.8 μmol nicotinic acid (NA) and 0.58 μmol nicotinamide (NAM). In addition to NA and NAM, the metabolites N¹ -methylnicotinamide (NMNAM), N¹ -methyl-2-pyridone-5-carboxamide (2-Py), and nicotinuric acid (NUA) were identified and quantified in the collected urine samples by stable isotope dilution a

SUBMITTER: Kremer JI 

PROVIDER: S-EPMC5900739 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature