Systematic review: probiotics in the management of lower gastrointestinal symptoms - an updated evidence-based international consensus.

ABSTRACT:

Background

In 2013, a systematic review and Delphi consensus reported that specific probiotics can benefit adult patients with irritable bowel syndrome (IBS) and other gastrointestinal (GI) problems.

Aim

To update the consensus with new evidence.

Methods

A systematic review identified randomised, placebo-controlled trials published between January 2012 and June 2017. Evidence was graded, previously developed statements were reassessed by an 8-expert panel, and agreement was reached via Delphi consensus.

Results

A total of 70 studies were included (IBS, 34; diarrhoea associated with antibiotics, 13; diarrhoea associated with Helicobacter pylori eradication therapy, 7; other conditions, 16). Of 15 studies that examined global IBS symptoms as a primary endpoint, 8

SUBMITTER: Hungin APS 

PROVIDER: S-EPMC5900870 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature