Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver.

ABSTRACT:

Background and aims

Nonalcoholic fatty liver disease is epidemiologically associated with hepatic and metabolic disorders. The aim of this study was to examine whether hepatic fat accumulation has a causal role in determining liver damage and insulin resistance.

Methods

We performed a Mendelian randomization analysis using risk alleles in PNPLA3, TM6SF2, GCKR and MBOAT7, and a polygenic risk score for hepatic fat, as instruments. We evaluated complementary cohorts of at-risk individuals and individuals from the general population: 1515 from the liver biopsy cohort (LBC), 3329 from the Swedish Obese Subjects Study (SOS) and 4570 from the population-based Dallas Heart Study (DHS).

Results

Hepatic fat was epidemiologically associated with liver damage, insulin resistance

SUBMITTER: Dongiovanni P 

PROVIDER: S-EPMC5900872 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature