Medicine-related beliefs predict attribution of symptoms to a sham medicine: A prospective study.

ABSTRACT:

Objectives

To investigate a range of possible predictors of nocebo responses to medicines.

Design

Prospective cohort study.

Methods

In total, 203 healthy adult volunteers completed measures concerning demographics, psychological factors, medicine-related beliefs, baseline symptoms, and symptom expectations before taking a sham pill, described as 'a well-known tablet available without prescription' that was known to be associated with several side effects. Associations between these measures and subsequent attribution of symptoms to the tablet were assessed using a hurdle model consisting of a joint logistic and truncated negative binomial regression.

Results

Men had an increased odds of attributing symptoms to the tablet OR = 1.52, and older participants had de

SUBMITTER: Webster RK 

PROVIDER: S-EPMC5900880 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature