Probiotics Affect One-Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression.

ABSTRACT:

Scope

Probiotics may influence one-carbon (C1) metabolism, neurotransmitters, liver function markers, or behavior.

Methods and results

Male adult Flinders Sensitive Line rats (model of depression, FSL; n = 22) received Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 (10⁹ or 10¹⁰ colony-forming units per day) or vehicle for 10 weeks. The controls, Flinders Resistant Line rats (FRL, n = 8), only received vehicle. C1-related metabolites were measured in plasma, urine, and different tissues. Monoamine concentrations were measured in plasma, hippocampus, and prefrontal cortex. Vehicle-treated FSL rats had higher plasma concentrations of betaine, choline, and dimethylglycine, but lower plasma homocysteine and liver S-adenosylmethionine (SAM) t

SUBMITTER: Tillmann S 

PROVIDER: S-EPMC5900923 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature