Evolution of dopamine receptors: phylogenetic evidence suggests a later origin of the DRD_2l and DRD_4rs dopamine receptor gene lineages.

ABSTRACT: Dopamine receptors are integral membrane proteins whose endogenous ligand is dopamine. They play a fundamental role in the central nervous system and dysfunction of dopaminergic neurotransmission is responsible for the generation of a variety of neuropsychiatric disorders. From an evolutionary standpoint, phylogenetic relationships among the DRD₁ class of dopamine receptors are still a matter of debate as in the literature different tree topologies have been proposed. In contrast, phylogenetic relationships among the DRD ₂ group of receptors are well understood. Understanding the time of origin of the different dopamine receptors is also an issue that needs further study, especially for the genes that have restricted phyletic distributions (e.g., DRD_2l

SUBMITTER: Opazo JC 

PROVIDER: S-EPMC5900934 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature