A biomimetic tumor tissue phantom for validating diffusion-weighted MRI measurements.

ABSTRACT:

Purpose

To develop a biomimetic tumor tissue phantom which more closely reflects water diffusion in biological tissue than previously used phantoms, and to evaluate the stability of the phantom and its potential as a tool for validating diffusion-weighted (DW) MRI measurements.

Methods

Coaxial-electrospraying was used to generate micron-sized hollow polymer spheres, which mimic cells. The bulk structure was immersed in water, providing a DW-MRI phantom whose apparent diffusion coefficient (ADC) and microstructural properties were evaluated over a period of 10 months. Independent characterization of the phantom's microstructure was performed using scanning electron microscopy (SEM). The repeatability of the construction process was investigated by generating a second phantom,

SUBMITTER: McHugh DJ 

PROVIDER: S-EPMC5900984 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature