Aucubin protects against pressure overload-induced cardiac remodelling via the β₃ -adrenoceptor-neuronal NOS cascades.

ABSTRACT:

Background and purpose

Aucubin, the predominant component of Eucommia ulmoides Oliv., has been shown to have profound effects on oxidative stress. As oxidative stress has previously been demonstrated to contribute to acute and chronic myocardial injury, we tested the effects of aucubin on cardiac remodelling and heart failure.

Experimental approach

Initially, H9c2 cardiomyocytes and neonatal rat cardiomyocytes pretreated with aucubin (1, 3, 10, 25 and 50 μM) were challenged with phenylephrine. Secondly, the transverse aorta was constricted in C57/B6 and neuronal NOS (nNOS)-knockout mice, then aucubin (1 or 5 mg·kg^-1 body weight day^-1 ) was injected i.p. for 25 days. Hypertrophy was evaluated by assessing morphological changes, echocardiographic paramete

SUBMITTER: Wu QQ 

PROVIDER: S-EPMC5900990 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature